Research programme: microRNA therapeutics - miRagen Therapeutics

Drug Profile

Research programme: microRNA therapeutics - miRagen Therapeutics

Alternative Names: AntimiR-15; AntimiR-155; AntimiR-208; AntimiRNA-15; LNA antimiR; MGN 7455; MGN-4893; mimics of the microRNA-183/96/182 - miRagen Therapeutics; miR-143/145; miR-15/195; miR-206; miR-208; miR-208/499; miR-29; miR-499; miR-92/126; miR-92a; MIRG-9103; miRNA-145 inhibitor; MRG-107

Latest Information Update: 08 May 2018

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At a glance

  • Originator University of Texas Southwestern Medical Center
  • Developer miRagen Therapeutics; Servier; University of Glasgow; University of Texas Southwestern Medical Center
  • Class Cardiovascular therapies; Eye disorder therapies; MicroRNAs; Neuroprotectants
  • Mechanism of Action MicroRNA inhibitors; MIRN145-microRNA-inhibitors; RNA modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Polycythaemia vera
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Amyotrophic lateral sclerosis; Cardiovascular disorders; Heart failure; Hypertrophic cardiomyopathy; Ischaemia; Postmyocardial infarction; Retinal disorders
  • Discontinued Coronary artery restenosis; Fibrosis; Polycythaemia vera; Pulmonary arterial hypertension

Most Recent Events

  • 02 May 2018 Preclinical trials in Retinal disorders in USA (Parenteral) before May 2018
  • 14 Mar 2018 miRagen plans a phase I safety and tolerability trial in Healthy volunteers (Intradermal) in the first half of 2018
  • 24 Jan 2018 Preclinical development for Heart failure and Postmyocardial infarction is ongoing in USA
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