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Galunisertib - Eli Lilly and Company

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Drug Profile

Galunisertib - Eli Lilly and Company

Alternative Names: LY-2157299

Latest Information Update: 31 Oct 2024

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At a glance

  • Originator Eli Lilly and Company
  • Developer AstraZeneca; Eli Lilly and Company; National Cancer Institute (USA); University of Oklahoma; Vanderbilt-Ingram Cancer Center; Weill Cornell Medical College
  • Class Antineoplastics; Pyrazoles; Pyridines; Pyrroles; Quinolines; Small molecules
  • Mechanism of Action Phosphotransferase inhibitors; Transforming growth factor beta1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Breast cancer; Cancer; Colorectal cancer; Glioblastoma; Glioma; Liver cancer; Myelodysplastic syndromes; Non-small cell lung cancer; Pancreatic cancer; Rectal cancer; Sarcoma; Solid tumours; Triple negative breast cancer

Most Recent Events

  • 10 Oct 2024 Eli Lilly completes a phase II trial in Glioblastoma (Second-line therapy or greater, Recurrent) in the US, Australia, Belgium, Canada, France, Germany, Italy, Poland, Netherlands, Spain (NCT01582269)
  • 30 Sep 2024 Eli Lilly initiates a phase I trial in Glioma (Second-line therapy or greater, Metastatic disease, Monotherapy, Combination therapy) in USA and Spain (PO) (NCT01682187)
  • 13 Feb 2024 University of Oklahoma and Eli Lilly complete a phase I trial in Sarcoma (Combination therapy, Newly diagnosed, Recurrent) in USA (PO) (NCT03206177)

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