ISF 35

Drug Profile

ISF 35

Alternative Names: Ad-CD154; Ad-ISF35; Ad-ISF35 transduced CLL B-cells; Adenovirus-CD 154; Immune Stimulatory Factor 35; ISF-35; rAd.CD40L

Latest Information Update: 06 Dec 2017

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At a glance

  • Originator Memgen LLC
  • Developer Memgen; The Leukemia & Lymphoma Society; University of California, San Diego; University of Texas M. D. Anderson Cancer Center
  • Class Cancer vaccines; Gene therapies
  • Mechanism of Action CD40 ligand stimulants; Immunostimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Chronic lymphocytic leukaemia
  • New Molecular Entity No

Highest Development Phases

  • Preclinical Malignant melanoma
  • No development reported Chronic lymphocytic leukaemia; Non-Hodgkin's lymphoma

Most Recent Events

  • 21 Nov 2017 Memgen withdraws a phase I/II trial prior to enrolment for Malignant melanoma (Combination therapy, Second-line therapy or greater, Late-stage disease, Metastatic disease) due to no IND serial number (Intratumoural) (NCT02719015)
  • 18 Nov 2015 Memgen has worldwide patent protection for ISF 35
  • 18 Nov 2015 Preclinical trials in Malignant melanoma (Refractory metastatic disease) in USA (Intratumoural)
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