Drug Profile


Alternative Names: TAK-438; TAKECAB; VONOPION® pack; Vonoprazan fumarate; VONOSAP® pack 400; VONOSAP® pack 800

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Takeda
  • Class Amines; Antiulcers; Pyridines; Pyrroles; Small molecules; Sulfonamides
  • Mechanism of Action Potassium-competitive acid blockers
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Duodenal ulcer; Erosive oesophagitis; Gastric ulcer; Gastro-oesophageal reflux; Helicobacter infections; Peptic ulcer; Reflux oesophagitis

Most Recent Events

  • 12 Oct 2018 Takeda completes a Phase II clinical trial in Gastro-oesophageal reflux (Treatment-experienced) in Belgium, Bulgaria, Czech Republic, Estonia, Poland, United Kingdom (PO) (NCT02743949; EudraCT2015-001154-14)
  • 24 Jun 2018 Biomarkers information updated
  • 02 Jun 2018 Efficacy and adverse events data from a phase III trial in Erosive oesophagitis presented at the Digestive Disease Week 2018 (DDW-2018)
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