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Balixafortide - Spexis

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Drug Profile

Balixafortide - Spexis

Alternative Names: POL-6326

Latest Information Update: 28 Apr 2025

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At a glance

  • Originator Polyphor
  • Developer Spexis
  • Class Anti-inflammatories; Anti-ischaemics; Antineoplastics; Cardiovascular therapies; Cyclic peptides; Epitopes; Macrocyclic compounds; Peptidomimetics; Vascular disorder therapies
  • Mechanism of Action CXCR4 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Breast cancer
  • Phase II Myocardial infarction; Stem cell mobilisation
  • Phase I Adenocarcinoma; Kidney disorders
  • No development reported Cancer; Coronary artery restenosis; COVID 2019 infections; Inflammation; Solid tumours; Wounds

Most Recent Events

  • 28 Apr 2025 No recent reports of development identified for preclinical development in COVID-2019-infections in Switzerland
  • 01 Dec 2023 Phase-I clinical trials in Adenocarcinoma (Spexis AG website, December 2023)
  • 20 Mar 2023 MedSIR withdraws a planned phase Ib/II trial in Breast cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) (IV), in Spain, prior to enrollment initiation, due to funder decision (NCT04826016)

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