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GSK 2586881

Drug Profile

GSK 2586881

Alternative Names: 2586881; APN-01; GSK2586881; Recombinant-human-soluble-angiotensin-converting-enzyme-2-Apeiron-Biologics; rhACE2; rhACE2-Apeiron-Biologics

Latest Information Update: 12 Feb 2019

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At a glance

  • Originator Apeiron Biologics
  • Developer Apeiron Biologics; GlaxoSmithKline
  • Class Antihypertensives; Antineoplastics; Recombinant proteins
  • Mechanism of Action ACE stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Acute lung injury; Adult respiratory distress syndrome; Pulmonary arterial hypertension
  • Discontinued Cancer; Diabetic nephropathies; Heart failure; Hypertension; Myocardial infarction

Most Recent Events

  • 25 Jan 2019 GlaxoSmithKline terminates a phase I trial in Adult respiratory distress syndrome (In volunteers) in Germany due to technical feasibility, operational considerations and futility in line with pre-specified criteria (IV) (NCT03000686)
  • 24 Jun 2018 Biomarkers information updated
  • 04 May 2018 GlaxoSmithKline re initiates phase I trial in Adult respiratory distress syndrome (In volunteers) in Germany (IV) (NCT03000686)
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