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APN 01

Drug Profile

APN 01

Alternative Names: APN-01; GSK-2586881; Recombinant-human-soluble-angiotensin-converting-enzyme-2-Apeiron-Biologics; rhACE2; rhACE2-Apeiron-Biologics

Latest Information Update: 29 Sep 2020

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At a glance

  • Originator Apeiron Biologics
  • Developer Apeiron Biologics; GlaxoSmithKline; University of British Columbia
  • Class Antihypertensives; Antineoplastics; Antivirals; Cardiovascular therapies; Heart failure therapies; Recombinant proteins
  • Mechanism of Action ACE stimulants; Virus internalisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Acute lung injury; Adult respiratory distress syndrome; COVID 2019 infections; Pulmonary arterial hypertension
  • Discontinued Cancer; Diabetic nephropathies; Heart failure; Hypertension; Myocardial infarction

Most Recent Events

  • 24 Sep 2020 Interim efficacy data from a phase II trial in COVID-2019 infections released by Apeiron Biologics
  • 28 Jun 2020 No recent reports of development identified for phase-I development in Adult-respiratory-distress-syndrome(In volunteers) in Germany (IV)
  • 03 Jun 2020 Phase-II clinical trials in COVID-2019 infections in USA, Russia (IV)
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