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Research programme: methionine aminopeptidase inhibitors - Zafgen

Drug Profile

Research programme: methionine aminopeptidase inhibitors - Zafgen

Alternative Names: ZGN 1258; ZGN 1345; ZGN 839; ZGN-201

Latest Information Update: 10 Oct 2018

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At a glance

  • Originator Zafgen
  • Class Anti-inflammatories; Hepatoprotectants; Obesity therapies; Small molecules
  • Mechanism of Action Methionine aminopeptidase 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Inflammation; Non-alcoholic steatohepatitis; Obesity; Prader-Willi syndrome

Most Recent Events

  • 04 Oct 2018 Pharmacodynamics data from preclinical trials in Prader-Willi syndrome released by Zafgen
  • 09 May 2018 Zafgen intends to initiate IND-enabling studies for non-alcoholic steatohepatitis (NASH) (Zafgen pipeline May,
  • 08 May 2018 Zafgen plans a phase I trial of ZGN 1258 for Prader-Willi Syndrome in the fourth quarter of 2018
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