Drug Profile


Alternative Names: Ketoprofen/amitriptyline/oxymetazoline; Ketoprofen/oxymetazoline/amitriptyline; OMS 103; OMS-103-HP; Oxymetazoline/amitriptyline/ketoprofen

Latest Information Update: 10 May 2017

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At a glance

  • Originator Omeros Corporation
  • Class Dibenzocycloheptenes; Imidazoles; Nonsteroidal anti-inflammatories; Phenylpropionates; Small molecules
  • Mechanism of Action Alpha 1 adrenergic receptor agonists; Alpha 2 adrenergic receptor agonists; Lipoxygenase-cyclooxygenase inhibitors; Serotonin uptake inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase III Postoperative pain

Most Recent Events

  • 16 Mar 2017 Omeros Corporation has patent protection for amitriptyline/oxymetazoline/ketoprofen for for the treatment of pain and inflammation in patients undergoing arthroscopic surgery in USA and ex-US countries
  • 03 Aug 2015 Amitriptyline/oxymetazoline/ketoprofen is still in phase III development for Postoperative pain
  • 17 Jun 2015 OMS 103HP licensed to Fagron in USA
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