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Veliparib - Abbvie

Drug Profile

Veliparib - Abbvie

Alternative Names: ABT 888; NSC 737664

Latest Information Update: 02 Oct 2021

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At a glance

  • Originator Abbott Laboratories; University of Alabama at Birmingham
  • Developer Abbott Laboratories; AbbVie; Georgetown University; Narodny onkologicky ustav; National Cancer Institute (USA); Northwestern University; University of Alabama at Birmingham
  • Class Amides; Antineoplastics; Benzimidazoles; Pyrrolidines; Small molecules
  • Mechanism of Action Poly(ADP-ribose) polymerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer; Non-small cell lung cancer; Ovarian cancer
  • Phase II/III Glioblastoma
  • Phase II Brain metastases; Colorectal cancer; Germ cell and embryonal neoplasms; Malignant melanoma; Pancreatic cancer; Rectal cancer; Solid tumours
  • Phase I/II Glioma; Head and neck cancer; Small cell lung cancer
  • No development reported Lymphoma; Multiple myeloma; Prostate cancer
  • Discontinued Liver cancer

Most Recent Events

  • 30 Sep 2021 Biomarkers information updated
  • 21 Jul 2021 AbbVie initiates an expanded-access programme for Breast cancer (Combination therapy, Metastatic disease) in the USA (NCT02985658)
  • 04 Jun 2021 Efficacy and adverse events data from a phase II trial in Germ cell cancer presented at the 57th Annual Meeting of the American Society of Clinical Oncology (ASCO-2021)
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