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Adavosertib - AstraZeneca

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Drug Profile

Adavosertib - AstraZeneca

Alternative Names: AZD-1775; L001739996-008U; MK-1775; MK-1775 hemihydrate

Latest Information Update: 13 Jul 2024

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At a glance

  • Originator Merck & Co
  • Developer AstraZeneca; Canadian Cancer Trials Group; Cancer Research UK; Dana-Farber Cancer Institute; Merck & Co; National Cancer Institute (USA); Samsung Medical Center; University of Birmingham; University of Texas M. D. Anderson Cancer Center; University of Washington
  • Class Aniline compounds; Antineoplastics; Piperazines; Pyrazoles; Pyridines; Pyrimidinones; Small molecules
  • Mechanism of Action WEE1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Cervical cancer; Colorectal cancer; Diffuse large B cell lymphoma; Fallopian tube cancer; Gastric cancer; Glioblastoma; Haematological disorders; Head and neck cancer; Non-small cell lung cancer; Ovarian cancer; Peritoneal cancer; Prostate cancer; Renal cell carcinoma; Small cell lung cancer; Solid tumours; Triple negative breast cancer; Uterine cancer; Vulvovaginal cancer

Most Recent Events

  • 31 May 2024 Adverse events and efficacy data from a phase-II trial in Non-small cell lung cancer presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)
  • 28 May 2024 Discontinued - Phase-I for Glioblastoma (Recurrent, Newly diagnosed, Combination therapy) in USA (PO)
  • 28 May 2024 Discontinued - Phase-I for Haematological disorders (Combination therapy, First-line therapy, Second-line therapy or greater) in USA (PO)

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