Drug Profile

Adavosertib - AstraZeneca

Alternative Names: AZD-1775; L001739996-008U; MK-1775; MK-1775 hemihydrate

Latest Information Update: 30 Jul 2026

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At a glance

Originator Merck & Co
Developer AstraZeneca; Canadian Cancer Trials Group; Cancer Research UK; Dana-Farber Cancer Institute; Merck & Co; National Cancer Institute (USA); Samsung Medical Center; University of Birmingham; University of Texas M. D. Anderson Cancer Center; University of Washington
Class Aniline compounds; Antineoplastics; Piperazines; Pyrazoles; Pyridines; Pyrimidinones; Small molecules
Mechanism of Action WEE1 protein inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Ovarian cancer
New Molecular Entity Yes

Preclinical Thyroid cancer
Discontinued Cervical cancer; Colorectal cancer; Diffuse large B cell lymphoma; Fallopian tube cancer; Gastric cancer; Glioblastoma; Haematological disorders; Head and neck cancer; Non-small cell lung cancer; Ovarian cancer; Peritoneal cancer; Prostate cancer; Renal cell carcinoma; Small cell lung cancer; Solid tumours; Triple negative breast cancer; Uterine cancer; Vulvovaginal cancer

02 Jun 2026 Efficacy and adverse events data from phase-II IGNITE-Cerala clinical trials presented at the 62^nd Annual Meeting of the American Society of Clinical Oncology (ASCO-2026)
17 Apr 2026 Preclinical trials in Thyroid cancer in USA (PO)
17 Apr 2026 Pharmacodynamics data from preclinical studies in Thyroid cancer presented at the 117^th Annual Meeting of the American Association for Cancer Research (AACR-2026)

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