Adavosertib - AstraZeneca

Drug Profile

Adavosertib - AstraZeneca

Alternative Names: AZD 1775; L001739996-008U; MK-1775 hemihydrate; MK1775

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Merck & Co
  • Developer AstraZeneca; Canadian Cancer Trials Group; Cancer Research UK; Merck & Co; National Cancer Institute (USA); Samsung Medical Center; University of Birmingham; University of Washington
  • Class Antineoplastics; Piperazines; Pyrazoles; Pyrimidinones; Small molecules
  • Mechanism of Action WEE1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Breast cancer; Endometrial cancer; Fallopian tube cancer; Non-small cell lung cancer; Ovarian cancer; Peritoneal cancer; Prostate cancer; Renal cell carcinoma; Small cell lung cancer; Solid tumours
  • Phase I Colorectal cancer; Glioblastoma; Haematological disorders; Head and neck cancer; Uterine cancer; Vulvovaginal cancer
  • Preclinical Diffuse large B cell lymphoma
  • Discontinued Cervical cancer

Most Recent Events

  • 31 Oct 2018 New York University School of Medicine plans a phase II trial for Acute myeloid leukaemia, Myelodysplastic syndrome and Myelofibrosis (Late stage disease; Monotherapy, Combination therapy), in November 2018 (NCT03718143)
  • 12 Sep 2018 AstraZeneca plans a phase II trial for Uterine cancer (Second-line therapy or greater, Recurrent) in USA (PO) in October 2018 (NCT03668340)
  • 04 Sep 2018 Phase-II clinical trials in Endometrial cancer (Combination therapy, Second-line therapy or greater, Metastatic disease) in USA (PO) (NCT03660826)
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