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Adavosertib - AstraZeneca

Drug Profile

Adavosertib - AstraZeneca

Alternative Names: AZD-1775; L001739996-008U; MK-1775; MK-1775 hemihydrate

Latest Information Update: 15 Jan 2024

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At a glance

  • Originator Merck & Co
  • Developer AstraZeneca; Canadian Cancer Trials Group; Cancer Research UK; Dana-Farber Cancer Institute; Merck & Co; National Cancer Institute (USA); Samsung Medical Center; University of Birmingham; University of Texas M. D. Anderson Cancer Center; University of Washington
  • Class Aniline compounds; Antineoplastics; Piperazines; Pyrazoles; Pyridines; Pyrimidinones; Small molecules
  • Mechanism of Action WEE1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Fallopian tube cancer; Non-small cell lung cancer; Ovarian cancer; Peritoneal cancer; Prostate cancer; Renal cell carcinoma; Small cell lung cancer; Solid tumours; Triple negative breast cancer
  • Phase I Haematological disorders; Head and neck cancer; Uterine cancer
  • Preclinical Diffuse large B cell lymphoma; Gastric cancer
  • No development reported Colorectal cancer; Glioblastoma; Vulvovaginal cancer
  • Discontinued Cervical cancer

Most Recent Events

  • 28 Nov 2023 H. Lee Moffitt Cancer Center and Research Institute complete a phase II trial in Non-small cell lung cancer (Combination therapy, Late stage disease, Metastatic disease) in USA (NCT02513563)
  • 02 Jun 2023 Efficacy and adverse events data from a phase II trial in Solid tumours presented at the at the 59th Annual Meeting of the American Society of Clinical Oncology (ASCO-2023)
  • 30 Apr 2023 The Netherlands Cancer Institute completes phase-II trial in Ovarian cancer (Combination therapy, Second-line therapy or greater) in the Netherlands (PO) (NCT01164995)
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