Adavosertib - AstraZeneca

Drug Profile

Adavosertib - AstraZeneca

Alternative Names: AZD 1775; L001739996-008U; MK-1775 hemihydrate; MK1775

Latest Information Update: 04 Jul 2018

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At a glance

  • Originator Merck & Co
  • Developer AstraZeneca; Canadian Cancer Trials Group; Cancer Research UK; Merck & Co; National Cancer Institute (USA); Samsung Medical Center; University of Birmingham; University of Washington
  • Class Antineoplastics; Piperazines; Pyrazoles; Pyrimidinones; Small molecules
  • Mechanism of Action WEE1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Breast cancer; Fallopian tube cancer; Non-small cell lung cancer; Ovarian cancer; Peritoneal cancer; Prostate cancer; Small cell lung cancer
  • Phase I/II Solid tumours
  • Phase I Colorectal cancer; Glioblastoma; Haematological disorders; Head and neck cancer; Uterine cancer; Vulvovaginal cancer
  • Preclinical Diffuse large B cell lymphoma
  • Discontinued Cervical cancer

Most Recent Events

  • 10 Jul 2018 MD Anderson Cancer Center, in collaboration with National Cancer Institute, plans a phase II trial for Ovarian cancer, Fallopian tube cancer, Peritoneal cancer (Combination therapy, Monotherapy, Metastatic disease, Recurrent, Second-line therapy or greater) in USA in September 2018 (NCT03579316)
  • 01 Jun 2018 Efficacy, adverse events and pharmacokinetics data from a phase I trial in Solid tumours presented at the 54th Annual Meeting of the American Society of Clinical Oncology (ASCO-2018)
  • 21 Apr 2018 Preclinical trials in Diffuse large B cell lymphoma (Combination therapy) in United Kingdom (PO)
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