Drug Profile


Alternative Names: ASLAN003; LAS 186323

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Laboratorios Almirall
  • Developer Almirall S.A.; ASLAN Pharmaceuticals
  • Class Antineoplastics; Antirheumatics; Small molecules
  • Mechanism of Action Dihydroorotate dehydrogenase inhibitors; P53 gene modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Acute myeloid leukaemia
  • Preclinical Cancer
  • No development reported Rheumatoid arthritis
  • Discontinued Multiple sclerosis

Most Recent Events

  • 20 Aug 2018 ASLAN 003 receives Orphan Drug status for Acute myeloid leukaemia in USA
  • 05 Jan 2018 Phase-II clinical trials in Acute myeloid leukaemia in Australia, Singapore (PO) (NCT03451084)
  • 13 Nov 2017 Singapore’s Health Sciences Authority approves IND application for initiation of a phase II trial in Acute myeloid leukaemia
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