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Tradipitant - Vanda Pharmaceuticals

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Drug Profile

Tradipitant - Vanda Pharmaceuticals

Alternative Names: LY-686017; VLY 686

Latest Information Update: 17 Jul 2025

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At a glance

  • Originator Eli Lilly and Company
  • Developer Eli Lilly and Company; National Institute on Alcohol Abuse and Alcoholism; Vanda Pharmaceuticals
  • Class Anti-inflammatories; Antipruritics; Antivirals; Anxiolytics; Behavioural disorder therapies; Chlorobenzenes; Gastrokinetics; Pyridines; Skin disorder therapies; Small molecules; Triazoles
  • Mechanism of Action Neurokinin 1 receptor antagonists; Substance P inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Motion sickness
  • Phase III Atopic dermatitis; COVID 2019 infections; Gastroparesis
  • Phase II Dyspepsia; Nausea and vomiting; Pruritus
  • Discontinued Alcoholism; Social phobia

Most Recent Events

  • 17 Jul 2025 Planned Prescription Drug User Fee Act (PDUFA) date for Motion sickness in USA (PO) is 2025-12-30
  • 07 May 2025 Preregistration for Motion sickness in USA (PO) (Vanda Pharmaceuticals pipeline, July 2025)
  • 25 Feb 2025 Phase-II clinical trials in Nausea and vomiting (In volunteers) in USA (PO) (NCT06804603)

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