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Tradipitant - Vanda Pharmaceuticals

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Drug Profile

Tradipitant - Vanda Pharmaceuticals

Alternative Names: LY-686017; Nereus; VLY 686

Latest Information Update: 05 Jan 2026

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At a glance

  • Originator Eli Lilly and Company
  • Developer Eli Lilly and Company; National Institute on Alcohol Abuse and Alcoholism; Vanda Pharmaceuticals
  • Class Anti-inflammatories; Antipruritics; Antivirals; Anxiolytics; Behavioural disorder therapies; Chlorobenzenes; Gastrokinetics; Pyridines; Skin disorder therapies; Small molecules; Triazoles
  • Mechanism of Action Neurokinin 1 receptor antagonists; Substance P inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Registered Motion sickness
  • Phase III Atopic dermatitis; Gastroparesis
  • Phase II Dyspepsia; Nausea and vomiting
  • No development reported COVID-19 pneumonia
  • Discontinued Alcoholism; Pruritus; Social phobia

Most Recent Events

  • 05 Jan 2026 Discontinued - Phase-I for Pruritus (In volunteers) in Switzerland (PO)
  • 05 Jan 2026 Discontinued - Phase-II for Pruritus (Treatment-experienced) in Germany (PO)
  • 05 Jan 2026 Discontinued - Phase-II for Pruritus (Treatment-experienced) in USA (PO)

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