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Pacritinib - CTI BioPharma

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Drug Profile

Pacritinib - CTI BioPharma

Alternative Names: ENPAXIQ; Epjevy; ONX-0803; Pacritinib; Pacritinib citrate; Pacritinibum; SB-1518

Latest Information Update: 16 Dec 2019

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At a glance

  • Originator S*BIO
  • Developer Cardiff University; CTI BioPharma; National Cancer Research Institute; Ohio State University Comprehensive Cancer Center; S*BIO; University of California, San Diego; University of Texas M. D. Anderson Cancer Center; Washington University School of Medicine; Weill Cornell Medical College
  • Class Antineoplastics; Macrocyclic compounds; Polycyclic bridged compounds; Pyrimidines; Pyrrolidines; Small molecules
  • Mechanism of Action Fms-like tyrosine kinase 3 inhibitors; Janus kinase-2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myeloproliferative disorders; Myelofibrosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Myelofibrosis
  • Phase II Acute myeloid leukaemia; Myelodysplastic syndromes; Myeloproliferative disorders
  • Phase I/II Graft-versus-host disease
  • Phase I Haematological disorders
  • Preclinical Chronic myeloid leukaemia
  • Suspended Colorectal cancer
  • Discontinued Lymphoma

Most Recent Events

  • 07 Dec 2019 Safety and efficacy data from the phase II PACIFICA trial in Myelofibrosis presented at the 61st Annual Meeting and Exposition of the American Society of Hematology (ASH-2019)
  • 28 Jul 2019 No recent reports of development identified for phase-I development in Acute-myeloid-leukaemia(Combination therapy) in USA (PO, Capsule)
  • 13 Mar 2019 CTI BioPharma expects to meet with the US FDA and report the determination of an optimal dose of pacritinib in mid-2019
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