CPI 613

Drug Profile

CPI 613

Alternative Names: Bylantra; CPI-613

Latest Information Update: 26 Sep 2018

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At a glance

  • Originator Cornerstone Pharmaceuticals; Stony Brook University
  • Developer Cornerstone Pharmaceuticals; National Cancer Institute (USA); Rafael Pharmaceuticals; Wake Forest University School of Medicine
  • Class Antineoplastics; Carboxylic acids; Coenzymes; Fatty acids; Small molecules; Thiophenes
  • Mechanism of Action Ketoglutarate dehydrogenase complex inhibitors; Pyruvate dehydrogenase complex inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelodysplastic syndromes; Burkitt's lymphoma; Peripheral T-cell lymphoma; T cell lymphoma; Acute myeloid leukaemia; Pancreatic cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Acute myeloid leukaemia; B cell lymphoma; Burkitt's lymphoma; Myelodysplastic syndromes; Pancreatic cancer; Small cell lung cancer; Solid tumours
  • Phase I/II Cancer
  • Phase I Colorectal cancer; Hodgkin's disease; Non-Hodgkin's lymphoma
  • No development reported Biliary cancer; Haematological malignancies

Most Recent Events

  • 07 Sep 2018 Rafael Holdings plans a phase III trial for Pancreatic cancer and Acute myeloid leukaemia
  • 22 Aug 2018 Sidney Kimmel Cancer Center at Thomas Jefferson University and Rafael Pharmaceuticals withdraws a phase II trial in Pancreatic cancer (Combination therapy, Late stage disease) prior to enrolement in USA (NCT03374852)
  • 13 Jul 2018 Rafael Pharmaceuticals plans clinical trials for Pancreatic cancer and Gastrointestinal cancer in Europe
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