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Pacibekitug - Tourmaline Bio

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Drug Profile

Pacibekitug - Tourmaline Bio

Alternative Names: PF-04236921; PF-4236921; TOUR-006

Latest Information Update: 26 Aug 2025

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At a glance

  • Originator Pfizer
  • Developer Pfizer; Tourmaline Bio
  • Class Anti-inflammatories; Antirheumatics; Cardiovascular therapies; Eye disorder therapies; Monoclonal antibodies
  • Mechanism of Action Interleukin 6 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Cardiovascular disorders; Graves ophthalmopathy; Kidney disorders
  • Preclinical Abdominal aortic aneurysm
  • Discontinued Crohn's disease; Rheumatoid arthritis; Systemic lupus erythematosus

Most Recent Events

  • 13 Aug 2025 Preclinical trials in Abdominal aortic aneurysm in USA (unspecified route)
  • 30 Jun 2025 Tourmaline completes a successful pre-IND interaction with the US FDA to conduct a phase II trial in abdominal aortic aneurysm
  • 20 May 2025 Pharmacodynamics and adverse event data from a phase II TRANQUILITY trial for Kidney disorders released byTourmaline Bio

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