Research programme: Dicer-substrate siRNA therapeutics - Dicerna

Drug Profile

Research programme: Dicer-substrate siRNA therapeutics - Dicerna

Alternative Names: CTNNB1 DsiRNA; DCR BCAT; DCR-HBV; DCR-HBVS; DCR-PCSK9; Dicer siRNA - Dicerna; DsiRNA - Dicerna; DsiRNA-EX conjugate - Dicerna; GalNAc-DsiRNA-EX conjugates; GalXC therapy

Latest Information Update: 04 Apr 2018

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At a glance

  • Originator Dicerna Pharmaceuticals
  • Class Antihyperglycaemics; Antihyperlipidaemics; Antineoplastics; Antirheumatics; Antivirals; Small interfering RNA
  • Mechanism of Action RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Preclinical Haematological malignancies; Hepatitis B; Hypercholesterolaemia
  • Research Liver disorders
  • No development reported Solid tumours
  • Discontinued Hepatitis C; Hyperlipidaemia; Rheumatoid arthritis; Type 2 diabetes mellitus

Most Recent Events

  • 08 Aug 2018 Dicerna announces intention to submit regulatory applications for clinical trials in Australia and New Zealand in the fourth quarter of 2018
  • 20 Apr 2018 Dicerna Pharmaceuticals intends to submit IND or CTA for Unknown indication, in the second half of 2018
  • 20 Apr 2018 Dicerna Pharmaceuticals plans a clinical trial for Unknown indication in the second half of 2018
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