Research programme: peripherally acting cannabinoid receptor CB1 antagonists - Jenrin Discovery

Drug Profile

Research programme: peripherally acting cannabinoid receptor CB1 antagonists - Jenrin Discovery

Alternative Names: JD-2000 series; JD-2114; JD-5000 series; JD-5006; JD-5037; JD-6000 series

Latest Information Update: 22 Dec 2017

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At a glance

  • Originator Jenrin Discovery
  • Developer Jenrin Discovery; National Institutes of Health (USA)
  • Class Small molecules
  • Mechanism of Action Cannabinoid 1 receptor inverse agonists; Cannabinoid receptor CB1 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Preclinical Atherosclerosis; Diabetes mellitus; Hyperlipidaemia; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Obesity

Most Recent Events

  • 14 Dec 2017 Prior to December 2017, preclinical trials in Non-alcoholic steatohepatitis in USA
  • 14 Dec 2017 US FDA approves IND application for JD 5037 in Non-alcoholic steatohepatitis
  • 14 Dec 2017 Jenrin Discovery plans to initiate a phase I trial for Non-alcoholic steatohepatitis in USA ,
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