Sonidegib - Novartis

Drug Profile

Sonidegib - Novartis

Alternative Names: Erismodegib; LDE-225; NVP-LDE-225; Odomzo

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Novartis
  • Developer Groupe Francophone des Myelodysplasies; Massachusetts General Hospital; Mayo Clinic; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (USA); Novartis; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Stanford University; University of Alabama at Birmingham
  • Class Antineoplastics; Biphenyl compounds; Morpholines; Phenyl ethers; Pyridines; Small molecules
  • Mechanism of Action SMO protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Basal cell cancer
  • Phase II Haematological malignancies; Medulloblastoma; Multiple myeloma; Solid tumours
  • Phase I/II Myelofibrosis; Pancreatic cancer
  • No development reported Breast cancer; Chronic myeloid leukaemia; Graft-versus-host disease; Hepatocellular carcinoma; Myelodysplastic syndromes; Oesophageal cancer; Ovarian cancer; Prostate cancer; Small cell lung cancer
  • Discontinued Basal cell nevus syndrome

Most Recent Events

  • 28 Jan 2018 No recent reports of development identified for phase-I development in Haematological-malignancies(Combination therapy) in USA (PO, Capsule)
  • 28 Jan 2018 No recent reports of development identified for phase-I development in Myelodysplastic-syndromes(Combination therapy) in USA (PO)
  • 28 Dec 2017 No recent reports of development identified for phase-I development in Oesophageal-cancer(Combination therapy, Late-stage disease) in USA (PO)
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