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Silmitasertib - Senhwa Biosciences

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Drug Profile

Silmitasertib - Senhwa Biosciences

Alternative Names: CX 4945

Latest Information Update: 15 Apr 2025

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At a glance

  • Originator Cylene Pharmaceuticals
  • Developer Cylene Pharmaceuticals; Penn State College of Medicine; Senhwa Biosciences; Stanford University School of Medicine
  • Class 3-ring heterocyclic compounds; Antineoplastics; Antivirals; Carboxylic acids; Naphthyridines; Small molecules
  • Mechanism of Action Casein kinase II inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Biliary cancer; Cholangiocarcinoma; Medulloblastoma
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Community-acquired pneumonia; COVID 2019 infections
  • Phase I/II Cholangiocarcinoma; Medulloblastoma; Solid tumours
  • Phase I Basal cell cancer
  • Preclinical Acute myeloid leukaemia; Precursor B-cell lymphoblastic leukaemia-lymphoma; Precursor T-cell lymphoblastic leukaemia-lymphoma
  • No development reported Giant lymph node hyperplasia; Multiple myeloma

Most Recent Events

  • 02 Apr 2025 Silmitasertib - Senhwa Biosciences is available for licensing as of 02 Apr 2025. www.senhwabio.com
  • 02 Apr 2025 Efficacy and adverse events data from a phase I trial in Basal cell cancer was released by Senhwa Biosciences
  • 29 Jan 2025 Pediatric Brain Tumor Consortium re-initiates phase I/II clinical trial in Medulloblastoma (Second-line therapy or greater, Recurrent, In adolescents, In adults, In children, In the elderly) in USA (PO) (NCT03904862)

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