Drug Profile


Alternative Names: 3K3A-activated protein C; 3K3A-APC non-anticoagulant mutant - ZZ Biotech; Activated-protein-C-analogue-University-of-Southern-California/Scripps-Research-Institute/ZZ-Biotech; Human-recombinant-3K3A-APC; Recombinant variant of human activated protein C (3K3A-APC)-ZZ-Biotech

Latest Information Update: 30 Jan 2018

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At a glance

  • Originator Socratech; The Scripps Research Institute; University of Southern California
  • Developer The Scripps Research Institute; University of Southern California; University of Sydney; ZZ Biotech
  • Class Antithrombotics; Blood proteins; Enzyme precursors; Recombinant proteins; Serine endopeptidases
  • Mechanism of Action Activated protein C receptor modulators; Factor V inhibitors; Factor VIII inhibitors; PAR 1 receptor modulators; PAR-3 receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Stroke
  • Preclinical Amyotrophic lateral sclerosis; Diabetic foot ulcer; Neurological disorders; Septic shock

Most Recent Events

  • 29 Jan 2018 Preliminary efficacy and adverse events data from a phase II RHAPSODY trial in Stroke released by ZZ Biotech
  • 09 Jan 2018 ZZ Biotech completes a phase II trial in Stroke in USA (IV) (NCT02222714)
  • 10 Jul 2017 Preclinical trials in Diabetic foot ulcer in USA (IV) before July 2017 (ZZ Biotech pipeline, July 2017)
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