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Drug Profile


Alternative Names: 3K3A-activated protein C; 3K3A-APC non-anticoagulant mutant - ZZ Biotech; Activated-protein-C-analogue-University-of-Southern-California/Scripps-Research-Institute/ZZ-Biotech; Human-recombinant-3K3A-APC; Recombinant variant of human activated protein C (3K3A-APC)-ZZ-Biotech

Latest Information Update: 28 Dec 2018

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At a glance

  • Originator Socratech; The Scripps Research Institute; University of Southern California
  • Developer The Scripps Research Institute; University of Southern California; University of Sydney; ZZ Biotech
  • Class Antithrombotics; Blood proteins; Enzyme precursors; Recombinant proteins; Serine endopeptidases
  • Mechanism of Action Activated protein C receptor modulators; Factor V inhibitors; Factor VIII inhibitors; PAR 1 receptor modulators; PAR-3 receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Stroke
  • Preclinical Diabetic foot ulcer
  • No development reported Amyotrophic lateral sclerosis; Neurological disorders; Septic shock

Most Recent Events

  • 28 Dec 2018 No recent reports of development identified for phase-I development in Stroke(In volunteers) in Austria (IV, Infusion)
  • 28 Dec 2018 No recent reports of development identified for preclinical development in Amyotrophic-lateral-sclerosis in USA (IV)
  • 28 Dec 2018 No recent reports of development identified for preclinical development in Neurological-disorders in USA (IV)
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