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Luspatercept - Bristol Myers Squibb

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Drug Profile

Luspatercept - Bristol Myers Squibb

Alternative Names: ACE-536; BMS-986346; Luspatercept-aamt; REBLOZYL; Reblozyl

Latest Information Update: 27 Feb 2026

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At a glance

  • Originator Acceleron Pharma
  • Developer Acceleron Pharma; Bristol-Myers Squibb; Celgene Corporation
  • Class Antianaemics; Disulfides; Immunoglobulin Fc fragments; Peptides; Recombinant fusion proteins
  • Mechanism of Action TGF-beta superfamily protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Beta-thalassaemia; Myelodysplastic syndromes
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Beta-thalassaemia; Myelodysplastic syndromes
  • Phase III Myelofibrosis
  • Phase II Alpha-thalassaemia
  • Discontinued Sickle cell anaemia

Most Recent Events

  • 24 Feb 2026 Efficacy and adverse events data from a phase II trial in Alpha-thalassaem released by Bristol-Myers Squibb
  • 06 Dec 2025 Pharmacodynamics data from the phase III COMMANDS trial in Hematological malignancies presented at the 67th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2025)
  • 06 Dec 2025 Updated efficacy and adverse events data from the phase IIIb MAXILUS trial in Myelodysplastic syndromes presented at the 67th American Society of Hematology Annual Meeting and Exposition (ASH-2025)

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