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Luspatercept - Bristol Myers Squibb

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Drug Profile

Luspatercept - Bristol Myers Squibb

Alternative Names: ACE-536; BMS-986346; Luspatercept-aamt; REBLOZYL; Reblozyl

Latest Information Update: 08 Oct 2024

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At a glance

  • Originator Acceleron Pharma
  • Developer Acceleron Pharma; Bristol-Myers Squibb; Celgene Corporation
  • Class Antianaemics; Disulfides; Immunoglobulin Fc fragments; Peptides; Recombinant fusion proteins
  • Mechanism of Action TGF-beta superfamily protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Beta-thalassaemia; Myelodysplastic syndromes
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Beta-thalassaemia; Myelodysplastic syndromes
  • Phase III Myelofibrosis
  • Phase II Alpha-thalassaemia
  • Discontinued Sickle cell anaemia

Most Recent Events

  • 08 Oct 2024 Discontinued - Preclinical for Sickle cell anaemia in USA (SC) (Bristol-Myers Squibb pipeline, October 2024)
  • 08 Oct 2024 Launched for Beta-thalassaemia in Canada (SC), prior to October 2024
  • 08 Oct 2024 Launched for Beta-thalassaemia in European Union (SC), prior to October 2024

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