Luspatercept - Acceleron Pharma/Celgene Corporation

Drug Profile

Luspatercept - Acceleron Pharma/Celgene Corporation

Alternative Names: ACE-536

Latest Information Update: 17 Jul 2018

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At a glance

  • Originator Acceleron Pharma
  • Developer Acceleron Pharma; Celgene Corporation
  • Class Antianaemics; Disulfides; Immunoglobulin Fc fragments; Peptides; Recombinant fusion proteins
  • Mechanism of Action TGF-beta superfamily protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Beta-thalassaemia; Myelodysplastic syndromes
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Beta-thalassaemia; Myelodysplastic syndromes
  • Phase II Anaemia; Myelofibrosis
  • No development reported Sickle cell anaemia

Most Recent Events

  • 02 Aug 2018 Acceleron plans the phase III COMMANDS trial for Myelodysplastic syndromes (First-line therapy) in the third quarter of 2018
  • 09 Jul 2018 The phase III BELIEVE met its primary and secondary endpoints
  • 28 Jun 2018 Celgene and Acceleron announces intention to submit NDA and MAA to US FDA and EMA for Myelodysplastic syndromes and Beta-thalassaemia in first half of 2019.
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