Autologous tumour cell vaccine - Champions Oncology/Gradalis/Mary Crowley

Drug Profile

Autologous tumour cell vaccine - Champions Oncology/Gradalis/Mary Crowley

Alternative Names: Bi-shRNAfurin; bi-shRNAfurin and GMCSF Autologous Tumor Cell Immunotherapy; FANG vaccine; FANG™; TAG vaccine; TGFbeta2 antisense + rhGMCSF vaccine; Vigil™; Vigil™ EATC

Latest Information Update: 10 Apr 2018

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At a glance

  • Originator Gradalis
  • Developer Gradalis; Mary Crowley Cancer Research Center
  • Class Cancer vaccines; Tumour cell vaccines
  • Mechanism of Action Furin expression inhibitors; Granulocyte-macrophage colony-stimulating factor expression stimulants; Immunostimulants; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase III Ovarian cancer
  • Phase II/III Breast cancer; Gynaecological cancer
  • Phase II Ewing's sarcoma; Liver metastases; Malignant melanoma
  • No development reported Solid tumours

Most Recent Events

  • 25 Apr 2018 Gradalis plans a phase III trial for Ewing's Sarcoma (Combination therapy, Metastatic disease, Second-line therapy or greater, In children, In adolescents, In adults, In the elderly) (Intradermal) (NCT03495921) in June 2018
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Solid-tumours(Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (Intradermal, Injection)
  • 01 Sep 2017 Gradalis completes a phase I trial in Malignant melanoma (Second-line therapy or greater, Combination therapy) in USA (NCT02574533)
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