Bi-shRNAfurin and GMCSF augmented autologous tumor cell immunotherapy - Champions Oncology/Gradalis/Mary Crowley

Drug Profile

Bi-shRNAfurin and GMCSF augmented autologous tumor cell immunotherapy - Champions Oncology/Gradalis/Mary Crowley

Alternative Names: Bi-shRNAfurin; bi-shRNAfurin and GMCSF Autologous Tumor Cell Immunotherapy; Engineered Autologous Tumor Cell Immunotherapy; FANG vaccine; FANG™; IND14205; TAG vaccine; TGFbeta2 antisense + rhGMCSF vaccine; Vigil™; Vigil™ EATC

Latest Information Update: 31 Aug 2018

Price : $50 *
* Final gross price and currency may vary according to local VAT and billing address.
* Your purchase entitles you to full access to the information contained in our drug profile at the time of purchase. A link to download a PDF version of the drug profile will be included in your email receipt. Adis is an information provider. We do not sell or distribute the pharmaceutical compounds written about in this database.

At a glance

  • Originator Gradalis
  • Developer Gradalis; Mary Crowley Cancer Research Center
  • Class Cancer vaccines; Cell therapies; Gene therapies; Immunotherapies; Tumour cell vaccines
  • Mechanism of Action Furin expression inhibitors; Granulocyte-macrophage colony-stimulating factor expression stimulants; Immunostimulants; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase III Ewing's sarcoma; Ovarian cancer
  • Phase II/III Breast cancer; Gynaecological cancer
  • No development reported Solid tumours
  • Discontinued Liver metastases; Malignant melanoma

Most Recent Events

  • 21 Aug 2018 Phase-III clinical trials in Ewing's Sarcoma (In adolescents, In children, Second-line therapy or greater, In adults, Combination therapy, Refractory metastatic disease, Recurrent, In the elderly) in USA (Intradermal) (NCT03495921)
  • 24 Jun 2018 Biomarkers information updated
  • 01 May 2018 Discontinued - Phase-I for Malignant melanoma (Combination therapy, Second-line therapy or greater) in USA (Intradermal) (Gradalis pipeline, August 2018)
Restricted Access

Oops, it looks like you don’t have a valid subscription to this content. To gain full access to the content and functionality of the AdisInsight database try one of the following.

  • with a username/password associated to an account with a valid subscription
  • Contact your organization’s admin about adding this content to your AdisInsight subscription
  • Request a trial

If you are a subscriber to this content then contact us at AsktheExpert.AdisInsight@springer.com so we can help.

Back to top