Masitinib - AB Science

Drug Profile

Masitinib - AB Science

Alternative Names: AB-1010; Alsitek; Masican; Masipro; Masitinib mesilate; Masitinib mesylate; Masiviera

Latest Information Update: 29 Oct 2018

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At a glance

  • Originator AB Science
  • Class Antiasthmatics; Antidementias; Antineoplastics; Antirheumatics; Benzamides; Nootropics; Piperazines; Pyridines; Small molecules; Thiazoles
  • Mechanism of Action Colony stimulating factor inhibitors; Focal adhesion protein-tyrosine kinase inhibitors; Lyn protein-tyrosine kinase inhibitors; Macrophage colony-stimulating factor receptor modulators; Mast cell inhibitors; Platelet-derived growth factor receptor antagonists; Protein tyrosine kinase inhibitors; Proto oncogene protein c-kit inhibitors; Proto-oncogene protein c-fyn modulators; Type 3 fibroblast growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mastocytosis; Amyotrophic lateral sclerosis; Gastric cancer; Gastrointestinal stromal tumours; Pancreatic cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Amyotrophic lateral sclerosis; Mastocytosis
  • Phase III Alzheimer's disease; Asthma; Colorectal cancer; Gastrointestinal stromal tumours; Malignant melanoma; Multiple myeloma; Multiple sclerosis; Pancreatic cancer; Peripheral T-cell lymphoma; Prostate cancer
  • Phase II/III Crohn's disease; Ovarian cancer
  • Phase II Breast cancer; Chronic obstructive pulmonary disease; Head and neck cancer; Non-small cell lung cancer; Parkinson's disease
  • Phase I/II Gastric cancer; Glioblastoma; Liver cancer; Oesophageal cancer
  • Preclinical Stroke
  • No development reported Psoriasis
  • Discontinued Mood disorders; Progressive supranuclear palsy; Rheumatoid arthritis

Most Recent Events

  • 22 Oct 2018 AB Science completes enrolment in the phase III AB09004 trial for Alzheimer's disease (Adjunctive treatment) in United Kingdom, Spain, Greece, Poland, Bulgaria and Slovakia (PO) (NCT01872598) (EudraCT2010-021218-50)
  • 26 Jun 2018 AB Science withdraws the request for re-examination of CHMP negative opinion for Masitinib for Amyotrophic lateral sclerosis
  • 24 Jun 2018 Biomarkers information updated
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