Research programme: GPCR modulators - Heptares Therapeutics

Drug Profile

Research programme: GPCR modulators - Heptares Therapeutics

Alternative Names: anti-PAR2 mAb - Heptares Therapeutics; calcitonin gene-related peptide (CGRP) modulators - Heptares Therapeutics; CNS disorder therapeutics - Heptares Therapeutics; HTL 0022562; M1/M4 agonist - Heptares Therapeutics; mGlus NAM - Heptares Therapeutics; muscarinic M1 agonists - Heptares Therapeutics; Orexin OX1 receptor antagonist - Heptares Therapeutics; Orexin OX2 agonists - Heptares Therapeutics

Latest Information Update: 16 Nov 2018

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At a glance

  • Originator Heptares Therapeutics
  • Developer Allergan; Heptares Therapeutics; Medical Research Council; Shire
  • Class Antibodies; Small molecules
  • Mechanism of Action Adenosine A2 receptor antagonists; Adenosine A2A receptor antagonists; Calcitonin gene-related peptide antagonists; G protein-coupled receptor modulators; Metabotropic glutamate receptor 5 modulators; Muscarinic M1 receptor agonists; Muscarinic M4 receptor agonists; Orexin receptor type 1 antagonists; Orexin receptor type 2 antagonists; PAR 2 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Cognition disorders; Migraine; Obsessive-compulsive disorders; Psychotic disorders
  • Research Atopic dermatitis
  • No development reported Anxiety disorders; Autistic disorder; CNS disorders; Depressive disorders; Drug abuse; Parkinson's disease; Sleep disorders; Unspecified

Most Recent Events

  • 07 Nov 2018 Heptares Therapeutics enters into a collaboration agreement with DyNAbind to develop GPCR modulators
  • 13 Mar 2018 Sosei regains worldwide rights from Teva to develop CGRP antagonists
  • 13 Mar 2018 Sosei plans a phase I trial in Migraine (In volunteers) in late 2018
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