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Avutometinib - Verastem Oncology

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Drug Profile

Avutometinib - Verastem Oncology

Alternative Names: CH 5127566; CH-5126766; CKI-27; R-7304; RG 7304; RO-5126766; VS-6766

Latest Information Update: 19 Apr 2024

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At a glance

  • Originator Chugai Pharmaceutical; Thomas Jefferson University
  • Developer Amgen; Chugai Pharmaceutical; Eli Lilly and Company; European Network of Gynaecological Oncological Trial Groups; Gynecologic Oncology Group; Memorial Sloan-Kettering Cancer Center; Roche; Royal Marsden NHS Foundation Trust; Verastem Oncology
  • Class Antineoplastics; Hydrazines; Ketones; Pyridazines; Small molecules
  • Mechanism of Action Mitogen-activated protein kinase inhibitors; Raf kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Ovarian cancer
  • Phase II Gynaecological cancer; Non-small cell lung cancer; Thyroid cancer; Uveal melanoma
  • Phase I/II Colorectal cancer; HER2 negative breast cancer; Malignant melanoma; Pancreatic cancer; Solid tumours
  • No development reported Multiple myeloma

Most Recent Events

  • 16 Apr 2024 M.D. Anderson Cancer Center plans a phase-II trial for Colorectal cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater; Inoperable/Unresectable) in the US in October 2024 (NCT06369259)
  • 14 Mar 2024 Verastem plans to initiate discussions with European and Japanese authorities for approval of avutometinib and defactinib combination in Ovarian cancer
  • 07 Mar 2024 Verastem Oncology announces intention to launch avutometinib in Ovarian Cancer in 2025
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