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Nelitolimod - TriSalus Life Sciences

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Drug Profile

Nelitolimod - TriSalus Life Sciences

Alternative Names: ISS-ODN SD-101; SD-101; SD101-Dynavax

Latest Information Update: 04 Dec 2024

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At a glance

  • Originator Dynavax Technologies
  • Developer Bristol-Myers Squibb; Dynavax Technologies; Merck & Co; National Cancer Institute (USA); Stanford University School of Medicine; TriSalus Life Sciences; University of California, Davis
  • Class Antineoplastics; Antivirals; Immunotherapies; Oligodeoxyribonucleotides
  • Mechanism of Action Toll-like receptor 9 agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Prostate cancer
  • Phase I/II B-cell lymphoma; Cholangiocarcinoma; Follicular lymphoma; Head and neck cancer; Liver cancer; Lymphoma; Malignant melanoma
  • Phase I Pancreatic cancer; Uveal melanoma
  • Preclinical Colorectal cancer
  • No development reported Haematological malignancies; Hepatitis C; Solid tumours

Most Recent Events

  • 27 Nov 2024 University of California plans a phase Ib trial for Liver cancer(Late-stage disease, Metastatic disease, Inoperable/unresectable, First-line therapy, Combination therapy) in an unknown location (Intrahepatic) in December 2024 (NCT06710223)
  • 03 Oct 2024 Nelitolimod is still in phase I trial for Uveal-melanoma (Combination therapy, First-line therapy, Metastatic disease) in USA (Intrahepatic, Infusion) (NCT04935229)
  • 03 Oct 2024 Nelitolimod is still in phase I trial for Uveal-melanoma (First-line therapy, Metastatic disease) in USA (Intrahepatic, Infusion) (NCT04935229)

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