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REC 4881

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Drug Profile

REC 4881

Alternative Names: REC-4881; TAK-733

Latest Information Update: 29 Nov 2024

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At a glance

  • Originator Exscientia; Takeda
  • Developer Recursion Pharmaceuticals
  • Class Antineoplastics; Small molecules
  • Mechanism of Action MAP kinase kinase 1 inhibitors; MAP kinase kinase 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Familial adenomatous polyposis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Familial adenomatous polyposis; Solid tumours
  • Discontinued Non-small cell lung cancer

Most Recent Events

  • 20 Nov 2024 Exscientia has been acquired and merged into Recursion Pharmaceuticals
  • 08 Aug 2024 Recursion Pharmaceuticals and Exscientia agree to co-promote and co-develop REC 4881 for familial adenomatous polyposis
  • 15 Jan 2024 Phase-II clinical trials in Solid tumours (Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO) (NCT06005974)

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