Lurbinectedin - PharmaMar

Drug Profile

Lurbinectedin - PharmaMar

Alternative Names: PM-01183; PM-1183; Tryptamicidin; Zepsyre

Latest Information Update: 04 Jul 2018

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At a glance

  • Originator PharmaMar
  • Developer Fundacion Instituto Valenciano de Oncologia; PharmaMar; Swiss Group for Clinical Cancer Research
  • Class 3-ring heterocyclic compounds; Acetates; Alkaloids; Antineoplastics; Dioxolanes; Indoles; Small molecules; Tetrahydroisoquinolines
  • Mechanism of Action Alkylating agents; Cell cycle inhibitors; RNA polymerase II inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes
  • Available For Licensing Yes - Cancer

Highest Development Phases

  • Phase III Ovarian cancer; Small cell lung cancer
  • Phase II Breast cancer; Mesothelioma; Non-small cell lung cancer; Pancreatic cancer; Sarcoma; Solid tumours
  • No development reported Leukaemia

Most Recent Events

  • 12 Jun 2018 PharmaMar requests the modification of primary endpoint from progression-free survival to overall survival for the phase III ATLANTIS trial
  • 04 Jun 2018 Efficacy and safety data from the phase II BASKET trial in Solid tumours released by PharmaMar
  • 01 Jun 2018 Interim safety, efficacy and pharmacokinetic data from the phase I trial in Solid tumours presented at the 54th Annual Meeting of the American Society of Clinical Oncology (ASCO-2018)
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