DM 199

Drug Profile

DM 199

Alternative Names: DM-199; DM-99; Recombinant human tissue kallikrein-1 - DiaMedica Therapeutics; rhKLK-1 - DiaMedica

Latest Information Update: 28 Jul 2018

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At a glance

  • Originator DiaMedica
  • Developer DiaMedica; DiaMedica Therapeutics
  • Class Antidementias; Antihyperglycaemics; Antirheumatics; Insulin sensitisers; Nootropics; Recombinant proteins
  • Mechanism of Action Tissue kallikrein-replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Stroke; Type 2 diabetes mellitus
  • Research Acute kidney injury
  • No development reported Alzheimer's disease; Diabetic nephropathies; Nephritis; Rheumatoid arthritis; Type 1 diabetes mellitus

Most Recent Events

  • 28 Jul 2018 No recent reports of development identified for preclinical development in Nephritis in USA
  • 28 May 2018 No recent reports of development identified for phase-I development in Diabetic-nephropathies in USA
  • 03 May 2018 DiaMedica Therapeutics intends to file an IND application and plans a phase IIa trial for Diabetic Nephropathies in USA in the second half of 2018
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