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Cebranopadol - Tris Pharma

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Drug Profile

Cebranopadol - Tris Pharma

Alternative Names: GRT-6005; PRK-101; TRN-228

Latest Information Update: 28 Mar 2025

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At a glance

  • Originator Grunenthal
  • Developer Grunenthal; Park Therapeutics; Tris Pharma
  • Class Cyclohexylamines; Drug withdrawal therapies; Indoles; Opioid analgesics; Small molecules; Spiro compounds
  • Mechanism of Action Nociceptin receptor agonists; Opioid mu receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes - Cancer pain

Highest Development Phases

  • Phase III Acute pain; Back pain; Postoperative pain
  • Phase II Cancer pain; Neuropathic pain
  • Phase I Pain; Substance-related disorders

Most Recent Events

  • 28 Mar 2025 No recent reports of development identified for phase-I development in Substance-related disorders(In volunteers) in USA (PO, Capsule)
  • 06 Mar 2025 Efficacy data from a phase III ALLEVIATE-2 trial for Postoperative pain released by Tris Pharma
  • 28 Jan 2025 Cebranopadol - Tris Pharma receives Fast Track designation for Back pain [PO,Tablet] in USA

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