Sitravatinib - Mirati Therapeutics

Drug Profile

Sitravatinib - Mirati Therapeutics

Alternative Names: MG-516; MG91516; MGCD-0516; MGCD-516

Latest Information Update: 25 Oct 2018

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At a glance

  • Originator MethylGene
  • Developer Columbia University; Mirati Therapeutics; University Health Network
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Axl receptor tyrosine kinase inhibitors; Eph family receptor antagonists; Platelet-derived growth factor receptor antagonists; Proto oncogene protein c met inhibitors; Proto oncogene protein c ret inhibitors; Proto oncogene protein c-kit inhibitors; Proto-oncogene protein c-mer inhibitors; Receptor protein-tyrosine kinase antagonists; RON protein inhibitors; TIE 2 receptor antagonists; Tropomyosin-related kinase antagonists; Vascular endothelial growth factor receptor 3 antagonists; Vascular endothelial growth factor receptor-1 antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Liposarcoma; Non-small cell lung cancer; Renal cell carcinoma; Soft tissue sarcoma; Urogenital cancer
  • Phase I Solid tumours; Squamous cell cancer

Most Recent Events

  • 22 Oct 2018 Updated efficacy data from a phase II trial in Non-small cell lung cancer released by Mirati Therapeutics
  • 22 Oct 2018 Mirati Therapeutics plans a pivotal phase III trial for Non-small cell lung cancer (Combination therapy, Second-line therapy or greater) in first half of 2019
  • 21 Oct 2018 Phase I trial in Solid tumours is still ongoing in South Korea and USA (NCT02219711)
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