APR 246

Drug Profile

APR 246

Alternative Names: APR-246; PRIMA-1-MET; UNII-Z41TGB4080

Latest Information Update: 09 Jan 2018

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At a glance

  • Originator Aprea
  • Developer Aprea; H. Lee Moffitt Cancer Center and Research Institute; Jules Bordet Institute; Peter MacCallum Cancer Centre; Victorian Cancer Agency
  • Class Antineoplastics; Quinuclidines; Small molecules
  • Mechanism of Action Tumour suppressor protein p53 stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer; Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Ovarian cancer
  • Phase I/II Acute myeloid leukaemia; Chronic myelomonocytic leukaemia; Malignant melanoma; Myelodysplastic syndromes; Oesophageal cancer
  • Preclinical Lung cancer
  • No development reported Haematological malignancies; Prostate cancer

Most Recent Events

  • 01 Jan 2018 Phase-I/II clinical trials in Malignant melanoma (Combination therapy, Inoperable/Unresectable, Metastatic disease, Second-line therapy or greater) in Belgium (IV) (NCT03391050)
  • 16 Oct 2017 Phase-I/II clinical trials in Oesophageal cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Australia (IV)
  • 02 Aug 2017 Aprea Therapeutics initiates enrolment in a phase Ib/II trial for Ovarian cancer (Recurrent, Second-line therapy)
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