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Research programme: gene-silencing oligonucleotides - Aceragen

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Drug Profile

Research programme: gene-silencing oligonucleotides - Aceragen

Alternative Names: 3GA platform - Aceragen; Gene-silencing oligonucleotides - Aceragen; GSO - Aceragen; Third generation antisense platform - Aceragen; TLR antagonists for B cell lymphomas - Aceragen; TLR anti-sense oligonucleotides - Aceragen

Latest Information Update: 20 Jan 2023

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At a glance

  • Originator Idera Pharmaceuticals
  • Developer Aceragen; Leiden University; National Cancer Institute (USA)
  • Class Anti-inflammatories; Antineoplastics; Antisense oligonucleotides; Oligonucleotides
  • Mechanism of Action Apolipoprotein B inhibitors; Carrier protein modulators; DUX4 protein modulators; Gene silencing; Immunomodulators; MicroRNA inhibitors; PCSK9 protein inhibitors; RNA interference; Toll-like receptor 7 antagonists; Toll-like receptor 8 antagonists; Toll-like receptor 9 antagonists; Toll-like receptor antagonists; Toll-like receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • No development reported Autoimmune disorders; B-cell lymphoma; Hypercholesterolaemia; Inflammation; Psoriasis
  • Discontinued Facioscapulohumeral muscular dystrophy; Interstitial cystitis; Ischaemia; Lupus nephritis; Uveitis

Most Recent Events

  • 17 Jan 2023 Idera Pharmaceuticals is now called Aceragen
  • 05 Apr 2021 Discontinued - Preclinical for Facioscapulohumeral muscular dystrophy in USA (unspecified route)
  • 05 Apr 2021 Discontinued - Preclinical for Interstitial cystitis in USA (unspecified route)
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