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Uprosertib - Laekna Therapeutics

Drug Profile

Uprosertib - Laekna Therapeutics

Alternative Names: GSK-2141795; GSK-2141795C; GSK-795; LAE 003; UPB 795

Latest Information Update: 03 Oct 2022

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At a glance

  • Originator GlaxoSmithKline
  • Developer Dana-Farber Cancer Institute; Laekna Therapeutics; National Cancer Institute (USA); National Comprehensive Cancer Network; Novartis Oncology; University of California at San Francisco
  • Class Amides; Antineoplastics; Furans; Pyrazoles; Small molecules
  • Mechanism of Action Proto oncogene protein c-akt inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase I Hereditary haemorrhagic telangiectasia; Proteus syndrome
  • Discontinued Acute myeloid leukaemia; Cervical cancer; Endometrial cancer; Lymphoma; Malignant melanoma; Multiple myeloma; Ovarian cancer; Solid tumours; Triple negative breast cancer; Uveal melanoma

Most Recent Events

  • 14 Sep 2022 Uprosertib - Laekna Therapeutics is available for licensing as of 14 Sep 2022. https://en.laekna.com/ (Laekna Therapeutics pipeline, September 2022)
  • 14 Sep 2022 Discontinued - Phase-II for Malignant melanoma (Combination therapy) in USA (PO) (Laekna Therapeutics pipeline, September 2022)
  • 14 Sep 2022 Discontinued - Phase-II for Multiple myeloma (Combination therapy, Second-line therapy or greater) in Canada (PO) (Laekna Therapeutics Pipeline, September 2022)
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