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Dabrafenib - Novartis

Drug Profile

Dabrafenib - Novartis

Alternative Names: 2118436; DRB 436; GSK 2118436A; GSK-2118436; Taffiner; Tafinlar; Tafinrar

Latest Information Update: 11 Jun 2019

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At a glance

  • Originator GlaxoSmithKline
  • Developer Dana-Farber Cancer Institute; GlaxoSmithKline; National Cancer Institute (USA); Novartis; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Fluorobenzenes; Pyrimidines; Small molecules; Sulfonamides; Thiazoles
  • Mechanism of Action Proto oncogene protein b raf inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Malignant melanoma; Thyroid cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Malignant melanoma; Non-small cell lung cancer
  • Registered Thyroid cancer
  • Phase II Brain metastases; Cancer; Colorectal cancer; Glioblastoma
  • Phase I/II Solid tumours

Most Recent Events

  • 05 Jun 2019 Pooled analysis adverse events and efficacy data from the COMBI-d and COMBI-v trials presented at the 55th Annual Meeting of American Society of Clinical Oncology (ASCO-2019)
  • 01 May 2019 Novartis completes a phase II trial in Malignant melanoma (In adolescents, In adults, In the elderly, Adjuvant therapy, Late-stage disease) in USA (PO) (NCT01682213)
  • 08 Apr 2019 Novartis Pharmaceuticals completes a phase I pharmacokinetics trial (In volunteers) in USA (PO) (NCT02873650)
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