Sapanisertib - Takeda Oncology

Drug Profile

Sapanisertib - Takeda Oncology

Alternative Names: HY-13328; INK-128; MLN-0128; TAK-228

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Intellikine
  • Developer Dana-Farber Cancer Institute; European Network for Translational Research in Ovarian Cancer (EUTROC); M. D. Anderson Cancer Center; National Cancer Institute (USA); Takeda; Takeda Oncology
  • Class Antineoplastics; Benzoxazoles; Pyrazolones; Pyrimidines; Small molecules
  • Mechanism of Action MTORC1 protein inhibitors; MTORC2 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Bladder cancer; Endometrial cancer; Glioblastoma; Neuroendocrine tumours; Soft tissue sarcoma; Thyroid cancer; Urogenital cancer
  • Phase I/II Liver cancer; Merkel cell carcinoma; Sarcoma
  • Phase I Cancer; Solid tumours
  • Discontinued Breast cancer; Multiple myeloma; Non-small cell lung cancer; Prostate cancer; Renal cell carcinoma; Waldenstrom's macroglobulinaemia

Most Recent Events

  • 27 Aug 2018 Takeda Pharmaceuticals International plans the DICE phase II trial for Ovarian, Fallopian tube, Peritoneal cancer and Endometrial cancer in United Kingdom (NCT03648489)
  • 03 Jul 2018 Millenium Pharmaceuticals completes a phase II trial in Breast cancer (combination therapy, second line or greater) in USA, France, Belgium (NCT02049957)
  • 02 Jul 2018 Millennium Pharmaceuticals and Takeda completes a phase I trial in Solid tumours (Combination therapy, Late-stage disease, Second-line therapy or greater) in United Kingdom, France, Spain, USA (PO) (NCT02327169)
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