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Sapanisertib - Takeda Oncology

Drug Profile

Sapanisertib - Takeda Oncology

Alternative Names: HY-13328; INK-128; MLN-0128; TAK-228

Latest Information Update: 15 Sep 2020

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At a glance

  • Originator Intellikine
  • Developer Dana-Farber Cancer Institute; European Network for Translational Research in Ovarian Cancer (EUTROC); M. D. Anderson Cancer Center; National Cancer Institute (USA); Takeda; Takeda Oncology
  • Class Antineoplastics; Benzoxazoles; Pyrazolones; Pyrimidines; Small molecules
  • Mechanism of Action MTORC1 protein inhibitors; MTORC2 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Bladder cancer; Endometrial cancer; Fallopian tube cancer; Glioblastoma; Neuroendocrine tumours; Ovarian cancer; Peritoneal cancer; Precursor cell lymphoblastic leukaemia-lymphoma; Soft tissue sarcoma; Thyroid cancer; Urogenital cancer
  • Phase I/II Liver cancer; Merkel cell carcinoma; Sarcoma
  • Phase I Cancer; Non-small cell lung cancer; Solid tumours
  • Discontinued Breast cancer; Multiple myeloma; Prostate cancer; Renal cell carcinoma; Waldenstrom's macroglobulinaemia

Most Recent Events

  • 18 Jun 2020 Phase-I clinical trials in Non-small cell lung cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater, Combination therapy) in USA (PO) (NCT04479306)
  • 29 May 2020 Efficacy and safety data from a phase I/II trial in Sarcoma presented at the 56th Annual Meeting of the American Society of Clinical Oncology (ASCO-2020)
  • 29 May 2020 Efficacy and adverse events data from a phase I trial in Solid tumours (Combination therapy) presented at the 56th Annual Meeting of the American Society of Clinical Oncology (ASCO-2020)
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