Drug Profile

Emiplacel - Pluri

Alternative Names: Allogeneic ex-vivo expanded placental adherent stromal cells; PLacental eXpanded cells; PLX PAD; PLX-PAD cell therapy

Latest Information Update: 07 Aug 2026

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At a glance

Originator Pluristem Therapeutics
Developer Charite - Universitatsmedizin Berlin; Pluri; Tel-Aviv Ichilov Medical Center
Class Antirheumatics; Ischaemic heart disorder therapies; Mesenchymal stem cell therapies; Stem cell therapies; Vascular disorder therapies
Mechanism of Action Cell differentiation modulators; Cell replacements; Dendritic cell modulators

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Preeclampsia; Thromboangiitis obliterans
New Molecular Entity No

Phase III Chronic limb-threatening ischemia; Muscle injury
Phase II Intermittent claudication; SARS-CoV-2 acute respiratory disease
Phase I/II Graft-versus-host disease
Phase I Osteoarthritis
No development reported Duchenne muscular dystrophy; Ischaemic heart disorders; Preeclampsia; Pulmonary arterial hypertension; Tendon injuries; Thromboangiitis obliterans

29 Jun 2026 Charite Universitatsmedizin Berlin terminates the phase-I PROTO–I trial in Osteoarthritis in Germany (Intra-articural) (CTIS2023-504212-15-00)
02 Feb 2026 Emiplacel is still in phase-III trial in Muscle injury (In the elderly, In adults, In neonates, In infants, In children, In adolescents) in USA, Bulgaria, Denmark, Germany, United Kingdom and Israel (IM) (NCT03451916)
08 Apr 2024 Pluri has patent protection for System and Methods for Immune Cells Expansion and Activation in Large Scale in the US

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