Momelotinib - Sierra Oncology

Drug Profile

Momelotinib - Sierra Oncology

Alternative Names: CYT-387; GS-0387; Momelotinib dihydrochloride

Latest Information Update: 09 Nov 2018

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At a glance

  • Originator Cytopia Research
  • Developer Gilead Sciences
  • Class Antineoplastics; Benzamides; Morpholines; Pyrimidines; Small molecules
  • Mechanism of Action ACVR1 protein inhibitors; Janus kinase 1 inhibitors; Janus kinase-2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myeloproliferative disorders
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Essential thrombocythaemia; Myelofibrosis; Myeloproliferative disorders; Pancreatic cancer; Polycythaemia vera
  • No development reported Non-small cell lung cancer

Most Recent Events

  • 01 Nov 2018 Efficacy, adverse events and pharmacodynamics data from a phase II trial in Myelofibrosis, Polycythemia vera and Essential thrombocythemia released by Sierra Oncology
  • 22 Aug 2018 Gilead Sciences completes the phase III Simplify 2 trial in Myelofibrosis in Canada, France, Germany, Israel, Italy, Spain, United Kingdom and the US before August 2018
  • 22 Aug 2018 Sierra Oncology acquires momelotinib from Gilead Sciences
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