Gedatolisib - Pfizer

Drug Profile

Gedatolisib - Pfizer

Alternative Names: PF-05212384; PF-5212384; PKI-587

Latest Information Update: 28 Jun 2018

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At a glance

  • Originator Wyeth
  • Developer Curie Institute; Eastchester Center for Cancer Care; Indiana University; Netherlands Cancer Institute; Pfizer; University of Florida
  • Class Antineoplastics; Morpholines; Piperidines; Small molecules; Triazines; Urea compounds
  • Mechanism of Action 1 Phosphatidylinositol 3 kinase inhibitors; MTOR protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia
  • Phase II Colorectal cancer; Non-small cell lung cancer
  • Phase I Breast cancer; Solid tumours
  • Discontinued Endometrial cancer

Most Recent Events

  • 01 Jun 2018 Efficacy and adverse events data from a phase I trial in Breast cancer presented at the 54th Annual Meeting of the American Society of Clinical Oncology (ASCO-2018)
  • 12 Mar 2018 Pfizer re-initiates patient enrolment in a phase I/II trial in Non-small cell lung cancer (Combination therapy, Inoperable/Unresectable, Metastatic disease, Late-stage disease) in USA (IV) (NCT02920450)
  • 17 Jan 2018 Abramson Cancer Center of the University of Pennsylvania and Translational Breast Cancer Research Consortium plans a phase Ib/II GLACIER trial (Combination therapy, Second-line therapy or greater) for Breast Cancer in USA (IV) (NCT03400254)
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