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Glasdegib - Pfizer

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Drug Profile

Glasdegib - Pfizer

Alternative Names: DAURISMO; PF 04; PF-04449913; PF-4449913

Latest Information Update: 03 Jan 2019

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At a glance

  • Originator Pfizer
  • Developer Grupo Espanol de Trasplante Hematopoyetico y Terapia Celular; H. Lee Moffitt Cancer Center and Research Institute; Pfizer
  • Class Antineoplastics; Benzimidazoles; Phenylurea compounds; Piperidines; Small molecules
  • Mechanism of Action Hedgehog cell-signalling pathway inhibitors; SMO protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Myelodysplastic syndromes; Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Registered Acute myeloid leukaemia
  • Phase II Chronic myelomonocytic leukaemia; Myelodysplastic syndromes; Myelofibrosis
  • Phase I/II Glioblastoma; Graft-versus-host disease
  • Phase I Cancer; Haematological malignancies; Solid tumours

Most Recent Events

  • 01 Dec 2018 Pharmacodynamics and safety data from the phase Ib/II BRIGHT 1003 trial in Acute myeloid leukaemia presented at the 60th Annual Meeting and Exposition of the American Society of Hematology (ASH-HEM-2018)
  • 26 Nov 2018 Glasdegib is still in Phase I clinical trials for Solid tumours in USA (PO) (Pfizer pipeline, November 2018)
  • 26 Nov 2018 Glasdegib is still in Phase I clinical trials for Haematological malignancies in Italy (PO) (Pfizer pipeline, November 2018)
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