Sevuparin - Modus Therapeutics/Mahidol Oxford Tropical Research Unit

Drug Profile

Sevuparin - Modus Therapeutics/Mahidol Oxford Tropical Research Unit

Alternative Names: DF-02; Low anticoagulant heparin - Modus Therapeutics

Latest Information Update: 17 Nov 2018

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At a glance

  • Originator Dilafor
  • Developer Arabian Gulf University; Mahidol Oxford Tropical Medicine Research Unit; Modus Therapeutics
  • Class Anti-inflammatories; Anticoagulants; Antimalarials; Antithrombotics; Heparins; Low molecular weight heparins; Polysaccharides
  • Mechanism of Action E-selectin inhibitors; Fibronectin receptor antagonists; L-selectin inhibitors; P selectin inhibitors; Thrombospondin antagonists; Von Willebrand factor inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Sickle cell anaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Falciparum malaria; Sickle cell anaemia

Most Recent Events

  • 07 Nov 2018 US FDA approves IND application for sevuparin in Sickle cell disease
  • 07 Nov 2018 Modus Therapeutics plans a phase I trial for sickle cell disease in USA (SC)
  • 18 Apr 2018 The US FDA grants rare pediatric disease designation to sevuparin for Sickle cell anaemia
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